Phase Ib study of poly-epitope peptide vaccination to thymidylate synthase (TSPP) and GOLFIG chemo-immunotherapy for treatment of metastatic colorectal cancer patients
نویسندگان
چکیده
منابع مشابه
Immunological monitoring of metastatic colorectal cancer patients undergoing active specific immunotherapy with a poly-epitope peptide vaccine (TSPP) to thymidylate synthase in combination with GOLFIG chemoimmunotherapy regimen
Background: TSPP is a 27 poly-epitope peptide anti-cancer vaccine which includes the amino acidic sequences of 3 known CTL-epitopes with HLA-A(*)02.01 binding motifs, contained in the thymidylate synthase (TS), a tumourassociated enzyme antigen critical for DNA synthesis and repair. The immunological and antitumor activity of TSPP has already been tested in preclinical studies, whose results of...
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Inflammatory status affects the antitumor activity of poly-epitope-peptide vaccination against the thymidylate synthase in metastatic colo-rectal cancer patients enrolled in TSPP/VAC-1 Phase Ib trial Pierpaolo Correale, Valerio Nardone, Cirino Botta, Elodia Martino, Pierpaolo Pastina, Cristina Ulivieri, Maria Grazia Rossetti, Antonella Fioravanti, Claudia Gandolfo, Francesco Carbone, Tatiana Co...
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چکیده ندارد.
15 صفحه اولImmunotherapy for Breast Cancer Treatment
Breast cancer, as a heterogeneous disease, includes a wide range of pathological and clinical behaviors. Current treatment protocols, including radiotherapy, chemotherapy, and hormone replacement therapy, are mainly associated with poor response and high rate of recurrence. Therefore, more efforts are needed to develop alternative therapies for this type of cancer. Immunotherapy, as a novel str...
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ژورنال
عنوان ژورنال: OncoImmunology
سال: 2015
ISSN: 2162-402X
DOI: 10.1080/2162402x.2015.1101205